Content-out Layout (Linda van Deursen)

Grids serve well to divide up a predefined canvas and guide how content fits onto a page, but when designing for the web’s fluid nature, we need something more… well, responsive. Enter ratios, which architects, sculptors, and book designers have all used in their work to help set the tone for their compositions, and to scale their material from sketch to final build. We can apply a similar process on the web by focusing on the tone and shape of our content first, then working outward to design fluid, ratio-based grid systems that invite harmony between content, layout, and screen. (alistapart.com)